InterPro domain: IPR029020

The entry represents the a structural domain found in ammonia and urea channels. The Amt/MEP/Rh ammonium transporters domain consists of a duplication of 2 structural repeats of five helices each plus one extra C-terminal helix [ 1 ]. Similarly, the urea transporter fold contains two homologous halves with opposite orientations in the membrane, each half with five transmembrane helices [ 2 ].

1. Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A. Science 305, 1587-94
2. Structure and permeation mechanism of a mammalian urea transporter. Proc. Natl. Acad. Sci. U.S.A. 109, 11194-9