InterPro domain: IPR028945
General Information
- Identifier IPR028945
- Description Get1 family
- Number of genes 108
- Gene duplication stats Loading...
- Associated GO terms GO:0071816
Abstract
In budding yeasts, Golgi to ER traffic protein 1 (Get1) is a component of the Golgi to ER traffic (GET) complex, which is composed of Get1, Get2 and Get3. The GET complex mediates posttranslational insertion of newly synthesised tail-anchored (TA) proteins to the endoplasmic reticulum (ER) membrane.The GET complex is composed of the homodimeric Get3 ATPase and its heterooligomeric receptor, Get1/2. Get1 stabilises an open dimer conformation of Get3 [ 1 ].
In metazoa, the homologue to Get1 is known as tail-anchored protein insertion receptor WRB, which is a receptor for ASNA1/TRC40 (Get3 in yeast) [ 2 ].
1. Get1 stabilizes an open dimer conformation of get3 ATPase by binding two distinct interfaces. J. Mol. Biol. 422, 366-75
2. WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane. J. Cell. Sci. 124, 1301-7