InterPro domain: IPR028939

Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain and a C-terminal dimerisation domain. This entry represents the N-terminal catalytic domain, which consists of an alpha/beta/alpha sandwich with a canonical NADP-binding Rossmann fold [ 1 ]. This type of NADP-binding domain is also found in F420-dependent NADP reductases [ 2 ].

1. Crystal structures of delta1-pyrroline-5-carboxylate reductase from human pathogens Neisseria meningitides and Streptococcus pyogenes. J. Mol. Biol. 354, 91-106
2. Structures of F420H2:NADP+ oxidoreductase with and without its substrates bound. EMBO J. 20, 6561-9