InterPro domain: IPR028938

Remodelling and spacing factor 1 (Rsf-1, also known as HBXAP) and SNF2h ATPase form the RSF chromatin remodelling complex [ 1 ]. Rsf-1 can induce chromosomal instability and is overexpressed in many types of cancer cells [ 2 , 3 , 4 ]. Its overexpression induces DNA damage response through ATM-Chk2-p53-p21 pathway [ 5 ]. It also interacts and collaborates with cyclin E1 in tumour development [ 6 ].

Rsf-1 is identical to the largest isoform of HBXAP (HBXAPalpha/Rsf-1), which interacts with hepatitis B virus X protein (HBx). HBXAP may function as a negative regulator for TNF-alpha-induced, NF-kappaB-mediated gene activation [ 7 ].

1. Rsf-1, a chromatin remodeling protein, induces DNA damage and promotes genomic instability. J. Biol. Chem. 285, 559-68
2. Rsf-1 overexpression correlates with poor prognosis and cell proliferation in colon cancer. Tumour Biol. 33, 6-10
3. Rsf-1 is overexpressed in non-small cell lung cancers and regulates cyclinD1 expression and ERK activity. Biochem. Biophys. Res. Commun. 420, 687-92
4. Rsf-1 expression in rectal cancer: with special emphasis on the independent prognostic value after neoadjuvant chemoradiation. J. Clin. Pathol. 65, 38260-9
5. ATM-dependent chromatin remodeler Rsf-1 facilitates DNA damage checkpoints and homologous recombination repair. Cell Cycle 13, 1485-91
6. Rsf-1, a chromatin remodelling protein, interacts with cyclin E1 and promotes tumour development. J. Pathol. 229, 133-43
7. Functional interaction between nuclear matrix-associated HBXAP and NF-kappaB. Exp. Cell Res. 298