InterPro domain: IPR028923

Phosphoribosylaminoimidazole-succinocarboxamide synthase ( 6.3.2.6 ) (SAICAR synthetase) catalyses the seventh step in the de novo purine biosynthetic pathway; the ATP-dependent conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylic acid and aspartic acid to SAICAR [ 1 ].

This domain can be found in SAICAR synthetases as a monofunctional protein from the bacteria (purC), fungi (ADE1) and plants (Pur7). In animals, this domain can be found in the N-terminal domain of a multifunctional enzyme (ADE2) possessing both the SAICAR synthetase and the phosphoribosylaminoimidazole carboxylase (AIR carboxylase) activity.

1. De novo purine nucleotide biosynthesis. Prog. Nucleic Acid Res. Mol. Biol. 42, 259-87