InterPro domain: IPR028836

General Information

  • Identifier IPR028836
  • Description Putative transmembrane ascorbate-dependent reductase CYB561 homologue

Abstract

Cytochrome b561 is a ferric-chelate reductase that reduces Fe3+ to Fe2+ before its transport from the endosome to the cytoplasm. It probably uses ascorbate as an electron donor [ 1 , 2 ].


1. An ascorbate-reducible cytochrome b561 is localized in macrophage lysosomes. Biochim. Biophys. Acta 1760, 1903-13
2. Three mammalian cytochromes b561 are ascorbate-dependent ferrireductases. FEBS J. 273, 3722-34

Species distribution

Gene table