InterPro domain: IPR028651

This family of chromatin modification proteins are involved in the regulation of cell cycle progression, apoptosis, and DNA repair. Members are found in yeast, animals and plants. They share significant sequence in their C-terminal regions containing PHD finger domains, which have been implicated in chromatin-mediated transcriptional regulation [ 1 ]. The family includes proteins YNG1, YNG2 and Pho23 from Saccharomyces cerevisiae [ 2 , 2 ], png1 and png2 from Schizosaccharomyces pombe [ 3 ], inhibitor of growth proteins ING1-5 from mammals [ 3 ], and Arabidopsis homologues ING1 (At3g24010) and ING2 (At1g54390) [ 4 ].

1. Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Mol. Cell. Biol. 20, 3807-16
2. Opposite role of yeast ING family members in p53-dependent transcriptional activation. J. Biol. Chem. 278, 19171-5
3. Phylogenetic analysis of the ING family of PHD finger proteins. Mol. Biol. Evol. 22, 104-16
4. Arabidopsis ING and Alfin1-like protein families localize to the nucleus and bind to H3K4me3/2 via plant homeodomain fingers. Plant J. 58, 511-24