InterPro domain: IPR028590

This entry represents the tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferases, including Trm7 from Saccharomyces cerevisiae. Trm7 methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of tRNA(Phe), tRNA(Trp) and tRNA(Leu(UAA)) [ 1 ]. It requires Trm732 for methylation of the cytidine at position 32 and Rtt10/Trm734 for methylation of the nucleotides at position 34 in substrate tRNAs [ 2 ].

This entry also includes FTSJ1 from human. FTSJ1 is a homologue of yeast Trm7 and may play a role in the regulation of translation. Mutations in FTSJ1 cause the mental retardation, X-linked 44 (MRX44), which is a disorder characterised by significantly below average general intellectual functioning associated with impairments in adaptative behaviour and manifested during the developmental period [ 3 ].

1. Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop. EMBO J. 21, 1811-20
2. Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop. RNA 18, 1921-33
3. Mutations in the FTSJ1 gene coding for a novel S-adenosylmethionine-binding protein cause nonsyndromic X-linked mental retardation. Am. J. Hum. Genet. 75, 305-9