InterPro domain: IPR028566

In Saccharomyces cerevisiae Rif1 interacts with Rif2 and Rap1 to regulate telomere length and establish telomeric silencing [ 1 ]. Despite the protein sequence similarity with yeast Rif1, human Rif1 does not bind to Rap1 and does not accumulate at functional telomeres. Human Rif1 is required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint) and is regulated by ATM and 53BP1 [ 2 ].

1. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev. 6, 801-14
2. Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev. 18, 2108-19