InterPro domain: IPR028386

This entry represents mammalian centromere protein C (CENP-C), budding yeast Mif2 and fission yeast centromere protein 3 (cnp3) [ 1 ]. They play an important role in assembly of the kinectochore, which is the microtubule-attachment sites that allow chromosome segregation on the mitotic spindle. It binds to the centromere and interacts with histones [ 2 , 3 ]. In budding yeast, it is phosphorylated by Aurora kinase Ipl1 [ 4 ]. In humans, CENP-C is a component of the CENPA-NAC complex, which is at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU [ 5 , 6 ].

1. Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Mol. Biol. Cell 6, 793-807
2. CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat. Cell Biol. 14, 604-13
3. Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes. Cell 145, 410-22
4. Architecture of the budding yeast kinetochore reveals a conserved molecular core. J. Cell Biol. 163, 215-22
5. The human CENP-A centromeric nucleosome-associated complex. Nat. Cell Biol. 8, 458-69
6. DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. Hum. Mol. Genet. 18, 3178-93