InterPro domain: IPR028361

Many glycoproteins of lower and higher eukaryotes are attached to the plasma membrane by means of a glycosylphosphatidylinositol (GPI) anchor, which is added onto newly synthesized proteins in the endoplasmic reticulum (ER). Precursors of GPI anchored proteins have a GPI anchoring signal at their C terminus;GPI-anchor transamidase (MEROPS identifier C13.005) removes the C-terminal peptide and replaces it with the preformed GPI [ 1 ].

1. Yeast Gpi8p is essential for GPI anchor attachment onto proteins. EMBO J. 15, 6575-83