InterPro domain: IPR028357
General Information
- Identifier IPR028357
- Description UDP-glucose 6-dehydrogenase, bacterial type
- Number of genes 27
- Gene duplication stats Loading...
- Associated GO terms GO:0000271 GO:0003979
Abstract
UDP-glucose 6-dehydrogenase is involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), a critical precursor for glycan synthesis. This process is required for capsule synthesis in some bacteria [ 1 , 2 , 3 ]. This entry represents bacterial type of the UDP-glucose 6-dehydrogenases. However, some non-bacterial proteins can also be found in this entry. This entry does not contain human UDP-glucose 6-dehydrogenase, which can be found in the eukaryotic type of the UDP-glucose 6-dehydrogenase ( IPR028356 ).
1. Region 2 of the Escherichia coli K5 capsule gene cluster encoding proteins for the biosynthesis of the K5 polysaccharide. Mol. Microbiol. 17, 611-20
2. Organization and characterization of the capsule biosynthesis locus of Streptococcus pneumoniae serotype 9V. Microbiology (Reading, Engl.) 148, 1747-55
3. Molecular characterization of hasB from an operon required for hyaluronic acid synthesis in group A streptococci. Demonstration of UDP-glucose dehydrogenase activity. J. Biol. Chem. 268, 7118-24