InterPro domain: IPR028346

This entry represents HAUS augmin-like complex subunit 2 from animals (HAUS2) and plants (AUG2) [ 1 , 2 ].

The HAUS (Homologous to AUgmin Subunits) individual subunits have been designated HAUS1 to HAUS8 [ 3 ]. In animals, HAUS augmin-like complex subunit 2 is a component of the HAUS augmin-like complex, which localises to the centrosomes and interacts with the gamma-tubulin ring complex (gamma-TuRC) [ 3 ]. The interaction between augmin and gamm-TuRC is important for spindle microtubule generation and affects the mitotic progression and cytokinesis [ 4 ]. HAUS2 may also increase the tension between spindle and kinetochore allowing for chromosome segregation during mitosis [ 5 ]. The HAUS augmin-like complex subunit 2 was previously known as centrosomal protein of 27kDa (Cep27).

In plants, the augmin complex contains 8 subunits, including two plant-specific subunits [ 5 ]. Despite lacking cetrosomes, the augmin complex in plants plays an important part in gamma-tubulin-dependent MT nucleation and the assembly of microtubule arrays during mitosis [ 5 ].

1. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr. Biol. 19, 816-26
2. Characterization of the Arabidopsis augmin complex uncovers its critical function in the assembly of the acentrosomal spindle and phragmoplast microtubule arrays. Plant Cell 24, 1494-509
3. Proteomic characterization of the human centrosome by protein correlation profiling. Nature 426, 570-4
4. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc. Natl. Acad. Sci. U.S.A. 106, 6998-7003