InterPro domain: IPR028307
General Information
- Identifier IPR028307
- Description Lin-54 family
- Number of genes 357
- Gene duplication stats Loading...
Abstract
This entry represents the lin-54 family of proteins. Members include lin-54 and tesmin. Lin-54 is a component of the DREAM (MuvB/DRM) complex, which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes [ 1 , 2 ]. Tesmin may have a role in spermatogenesis [ 3 , 4 ].
1. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. Mol. Cell 26, 539-51
2. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. Cell Cycle 6, 1903-13
3. Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes. J. Inorg. Biochem. 88, 183-91
4. Native tesmin is a 60-kilodalton protein that undergoes dynamic changes in its localization during spermatogenesis in mice. Biol. Reprod. 68, 1861-9