InterPro domain: IPR028283

This entry represents the C-terminal region of WASH complex subunit 7 (WASH7), also known as subunit 4 or KIAA1033 [ 1 ]. The WASH complex is present at the surface of endosomes and recruits and activates the Arp2/3 complex to induce mediatedactin nucleation. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting [ 2 ]. This C-terminal domain is predicted to include a transmembrane region.

1. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. Dev. Cell 17, 712-23
2. WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond. Trends Cell Biol. 20, 650-61