InterPro domain: IPR028261

General Information

  • Identifier IPR028261
  • Description Dihydroprymidine dehydrogenase domain II
  • Number of genes 153
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Abstract

Domain II of the enzyme dihydroprymidine dehydrogenase binds FAD. Dihydroprymidine dehydrogenase catalyses the first and rate-limiting step of pyrimidine degradation by converting pyrimidines to the corresponding 5,6- dihydro compounds [ 1 ]. This domain carries two Fe4-S4 clusters.


1. Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer. J. Biol. Chem. 277, 13155-66

Species distribution

Gene table