InterPro domain: IPR028226

General Information

  • Identifier IPR028226
  • Description Protein LIN37
  • Number of genes 113
  • Gene duplication stats Loading...
  • Associated GO terms GO:0017053  

Abstract

This entry represent LIN37 and related proteins from animals and plants. In humans, LIN37 is a component of the DREAM (MuvB/DRM) complex, which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes [ 1 , 2 ].


1. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. Mol. Cell 26, 539-51
2. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. Cell Cycle 6, 1903-13

Species distribution

Gene table