InterPro domain: IPR028222
General Information
- Identifier IPR028222
- Description AP-5 complex subunit zeta-1
- Number of genes 109
- Gene duplication stats Loading...
- Associated GO terms GO:0044599
Abstract
AP-5 complex subunit zeta-1 is a component of the fifth Adaptor-Protein complex (AP-5) [ 1 ]. Adaptor protein (AP) complexes facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles. AP-5 is involved in trafficking proteins from endosomes towards other membranous compartments [ 2 ]. There are genetic links between AP-5 and hereditary spastic paraplegia, a group of human genetic disorders characterised by progressive spasticity in the lower limbs [ 3 ].
1. And now there are five: a new player in intracellular trafficking pathways. PLoS Biol. 9, e1001173
2. The fifth adaptor protein complex. PLoS Biol. 9, e1001170
3. A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. PLoS Biol. 8, e1000408