InterPro domain: IPR028191

This entry represents the N-terminal WASH homology domain (WAHD) of WASH complex subunit 7 (WASH7), also known as subunit 4 or KIAA1033 [ 1 ]. This domain comprises the WAHD1 and the TBR (tubulin-binding region) domains [ 2 ]. In species such as Drosophila this protein is the only component of the 'complex'. WASH is a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerisation [ 2 ].

1. WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond. Trends Cell Biol. 20, 650-61
2. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. Dev. Cell 17, 712-23