InterPro domain: IPR028162

General Information

  • Identifier IPR028162
  • Description Siroheme biosynthesis protein Met8, C-terminal
  • Number of genes 2
  • Gene duplication stats Loading...

Abstract

This entry represents the C-terminal domain of the siroheme biosynthesis protein Met8. In Saccharomyces cerevisiae, Met8 is a bifunctional dehydrogenase ( 1.3.1.76 ) and ferrochelatase ( 4.99.1.4 ) [ 1 ]. It catalyses the final two steps in the biosynthesis of sirohaem, involving a NAD(+)-dependent dehydrogenation of precorrin-2 to generate sirohydrochlorin followed by ferrochelation to yield sirohaem [ 2 ].


1. The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase. EMBO J. 21, 2068-75
2. The role of Saccharomyces cerevisiae Met1p and Met8p in sirohaem and cobalamin biosynthesis. Biochem. J. 338 ( Pt 3), 701-8

Species distribution

Gene table