InterPro domain: IPR028160
General Information
- Identifier IPR028160
- Description Ribosome biogenesis protein Slx9-like
- Number of genes 115
- Gene duplication stats Loading...
- Associated GO terms GO:0000462 GO:0005730 GO:0030686 GO:0030688
Abstract
Slx9 is required for pre-rRNA processing. In Saccharomyces cerevisiae, Slx9 is associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor [ 1 ].
The early stages of ribosomes biogenesis includes processing of the 35S pre-ribosomal RNA transcript into the mature 18S, 5.8S, and 25S rRNA molecules. The 35S precursor contains external transcribed spacer elements (5' and 3'-ETS) at either end as well as internal transcribed spacers (ITS1 and ITS2) that separate the mature sequences [ 2 ]. Slx9 is implicated in the processing events that remove the ITS1 spacer sequences [ 2 ].
This entry also includes the FAM207A proteins from mammals.
1. Slx9p facilitates efficient ITS1 processing of pre-rRNA in Saccharomyces cerevisiae. RNA 12, 2005-13