InterPro domain: IPR028131

This entry represents a family of tubulinyl-Tyr carboxypeptidases. These regulate microtubule function by removing a C-terminal tyrosine residue from alpha-tubulin [ 1 ]. Tubulinyl-Tyr carboxypeptidase 1 is also known as vasohibin-1 (VASH1), and it act as an angiogenesis inhibitor [ 2 , 3 ]. VASH1 is predominantly expressed in endothelial cells and it is induced by vascular endothelial growth factor (VEGF) or fibroblast growth factor 2 (FGF-2). Tubulinyl-Tyr carboxypeptidase 2 (VASH2) is thought to be expressed in cells other than endothelial cells [ 4 , 5 ].

Angiogenesis, the formation of new vessels from existing ones, is a key event both under physiological and pathologic conditions. It is determined by the local balance between angiogenesis stimulators and inhibitors.

1. Vasohibins encode tubulin detyrosinating activity. Science 358, 1453-1456
2. Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis. J. Clin. Invest. 114, 898-907
3. The vasohibin family: a negative regulatory system of angiogenesis genetically programmed in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 27, 37-41
4. Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin. Arterioscler. Thromb. Vasc. Biol. 26, 1051-7
5. The vasohibin family: a novel family for angiogenesis regulation. J. Biochem. 153, 5-11