InterPro domain: IPR028058

The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This entry represents the N-terminal tetratricopeptide repeat [ 1 , 2 ]. Fis1 is an outer mitochondrial membrane protein that plays a role in mitochondrial membrane fission [ 3 ].

1. The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. J. Mol. Biol. 334, 445-58
2. Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold. Proteins 54, 153-6
3. Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J. Cell Biol. 151, 367-80