InterPro domain: IPR028055

This entry represents the C-terminal domain of YidC/Oxa1 proteins from some species and full length protein from other species. This domain appears to be univeral among bacteria (although absent from Archaea). YidC is a bacterial membrane protein which is required for the insertion and assembly of inner membrane proteins [ 1 , 2 ]. The well-characterised YidC protein from Escherichia coli and its close homologues contain a large N-terminal periplasmic domain ( IPR028053 ).

1. The crystal structure of the periplasmic domain of the Escherichia coli membrane protein insertase YidC contains a substrate binding cleft. J. Biol. Chem. 283, 9350-8
2. Crystal structure of the major periplasmic domain of the bacterial membrane protein assembly facilitator YidC. J. Biol. Chem. 283, 5208-16