InterPro domain: IPR028020

This entry represents the DEUBiquitinase ADaptor (DEUBAD) domain from Asx and homologues, which contain a characteristic LXXLL motif [ 1 , 2 ], detected in diverse transcription factors, coactivators and co-repressors and is implicated in mediating interactions between them [ 3 ]. This domain interacts with the UCH37-like domain (ULD) from Calypso and BAP1 deubiquitinases (DUBs), an interaction that is required for DUB activity activation [ 4 , 5 , 6 , 7 ].

1. Functional conservation of Asxl2, a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene Asx. PLoS ONE 4, e4750
2. Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice. Dev. Biol. 337, 9-15
3. The LxxLL motif: a multifunctional binding sequence in transcriptional regulation. Trends Biochem. Sci. 30, 66-9
4. The HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modifications. Cell Cycle 11, 119-31
5. BAP1/ASXL1 recruitment and activation for H2A deubiquitination. Nat Commun 7, 10292
6. Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Nat Commun 9, 4385
7. Structural Basis for the Activation of the Deubiquitinase Calypso by the Polycomb Protein ASX. Structure 27, 528-536.e4