InterPro domain: IPR027706

Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase) ( 3.1.3.27 ) dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol in cardiolipin biosynthesis. Cardiolipin is a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes. The inverted phosphatase motif includes the highly conserved DKD triad [ 1 , 2 ]. In Saccharomyces cerevisiae, Gep4 is required for the stability of respiratory chain supercomplexes and for growth at elevated temperature, in presence of ethidium bromide or in absence of prohibitins [ 3 ].

Chloroplastic phosphatidylglycerophosphate phosphatase is involved in the biosynthesis of phosphatidylglycerol (PG), a phosphoglycerolipid present in chloroplastic thylakoid membranes and has a photosynthetic function [ 3 ].

1. A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4. EMBO J. 29, 1976-87
2. The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J. Cell Biol. 184, 583-96
3. Isolation and characterization of a phosphatidylglycerophosphate phosphatase1, PGPP1, in Chlamydomonas reinhardtii. Plant Physiol. Biochem. 92, 56-61