InterPro domain: IPR027516
General Information
- Identifier IPR027516
- Description Eukaryotic translation initiation factor 3 subunit C
- Number of genes 276
- Gene duplication stats Loading...
- Associated GO terms GO:0003743 GO:0003723 GO:0031369 GO:0006413 GO:0005852
Abstract
Eukaryotic translation initiation factor 3 subunit C (EIF3C) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. EIF3C appears to be important for eIF3 activity [ 1 ]. Its N-terminal domain mediates eIF3 binding to eIF1 and eIF5 [ 2 ], and its C-terminal PCI domain forms an important intermolecular bridge between eIF3 and the 40S ribosome [ 3 ].
1. Reconstitution reveals the functional core of mammalian eIF3. EMBO J. 26, 3373-83
2. Functional characterization of the role of the N-terminal domain of the c/Nip1 subunit of eukaryotic initiation factor 3 (eIF3) in AUG recognition. J. Biol. Chem. 287, 28420-34
3. The eIF3c/NIP1 PCI domain interacts with RNA and RACK1/ASC1 and promotes assembly of translation preinitiation complexes. Nucleic Acids Res. 40, 2683-99