InterPro domain: IPR027512

General Information

  • Identifier IPR027512
  • Description Eukaryotic translation initiation factor 3 subunit A
  • Number of genes 260
  • Gene duplication stats Loading...
  • Associated GO terms GO:0005852  

Abstract

Eukaryotic translation initiation factor 3 subunit A is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. However, the subunit is not required for the general function of eIF3 in translation initiation [ 1 ]. It may play a role in regulating translation of a subset of mRNAs and in regulating cell cycle progression and cell proliferation [ 2 ].


1. The translational regulator eIF3a: the tricky eIF3 subunit! Biochim. Biophys. Acta 1806, 275-86
2. Role of eIF3a in regulating cell cycle progression. Exp. Cell Res. 315, 1889-94

Species distribution

Gene table