InterPro domain: IPR027484

This superfamily represents the N-terminal domain of the phosphatidylinositol-4-phosphate 5-kinase (PIP5K). It has a 2-layer sandwich structure [ 1 ]. PIP5K catalyses the formation of phosphoinositol-4,5-bisphosphate via the phosphorylation of phosphatidylinositol-4-phosphate, a precursor in the phosphinositide signalling pathway [ 2 ].

1. Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. Cell 94, 829-39
2. Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J. Biol. Chem. 273, 8741-8