InterPro domain: IPR027363

Methylthioribose-1-phosphate isomerase, an enzyme of the methionine salvage pathway, catalyses the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [ 1 ].

The enzyme can be divided into two domains, the N-terminal domain and the C-terminal domain. The N-terminal domain folds into a three-stranded antiparallel beta-sheet followed by five alpha-helices [ 2 ].

1. A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO. Science 302, 286-90
2. Crystal structure of 5-methylthioribose 1-phosphate isomerase product complex from Bacillus subtilis: implications for catalytic mechanism. Protein Sci. 17, 126-35