InterPro domain: IPR027317

This entry includes the PGAP2-interacting protein from mammals and the protein Cwh43 from yeasts.

Cwh43 is involved in the maintenance of cell wall integrity. It is required for the replacement of the diacylglycerol moiety by ceramides during GPI (glycosylphosphatidylinositol) - anchor maturation [ 1 , 2 , 3 ]. The C-terminal region of Cwh43 is homologous to mammalian PGAP2-interacting protein (PGAP2IP), and is essential for the ability to remodel GPI lipids to ceramides. The N-terminal region of yeast Cwh43 contains a sequence homologous to mammalian PGAP2 (post-GPI attachment to proteins factor 2). The association of the the N-terminal region enhances the lipid remodelling to ceramides by the C-terminal region. Mammalian PGAP2 and PGAP2-interacting protein seems to share these activities [ 4 ].

1. Saccharomyces cerevisiae YCRO17c/CWH43 encodes a putative sensor/transporter protein upstream of the BCK2 branch of the PKC1-dependent cell wall integrity pathway. Yeast 18, 827-40
2. Saccharomyces cerevisiae CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides. Mol. Biol. Cell 18, 4304-16
3. CWH43 is required for the introduction of ceramides into GPI anchors in Saccharomyces cerevisiae. Mol. Microbiol. 65, 1493-502