InterPro domain: IPR027238

This entry represents RuvB-like proteins, including RuvB-like 1 and 2 (Rvb1 and Rvb2).

Rvb1 is similar to Rvb2. They possesses ATP-dependent DNA helicase (5' to 3') activity [ 1 ]. They are components of the INO80 complex, which is involved in transcriptional regulation, DNA replication and probably DNA repair [ 2 ]. They are involved in multiple processes such as chromatin remodeling and pre-rRNA processing [ 3 ]. In mammals, they are components of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A [ 4 ].

1. Purification, cloning, and characterization of a profibrinolytic plasminogen-binding protein, TIP49a. J. Biol. Chem. 276, 179-86
2. Rvb1p and Rvb2p are essential components of a chromatin remodeling complex that regulates transcription of over 5% of yeast genes. J. Biol. Chem. 276, 16279-88
3. The R2TP complex: discovery and functions. Biochim. Biophys. Acta 1823, 101-7
4. Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage. Mol. Cell. Biol. 28, 2690-700