InterPro domain: IPR027235
General Information
- Identifier IPR027235
- Description Prefoldin subunit 2
- Number of genes 143
- Gene duplication stats Loading...
- Associated GO terms GO:0016272 GO:0006457
Abstract
This entry represents prefoldin subunit 2 (PFD2, also known as Gim4 in budding yeasts). PFD2 is part of the prefoldin heterohexamer complex (consists of two PFD-alpha type and four PFD-beta type subunits) that binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it [ 1 ]. It binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for non-native proteins [ 2 , 3 ].
1. A novel protein complex promoting formation of functional alpha- and gamma-tubulin. EMBO J. 17, 952-66
2. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell 93, 863-73
3. S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. Mol. Cell 28, 28-40