InterPro domain: IPR027180

This entry includes the chromatin structure remodeling complex (RSC) subunits RSC1, RSC2 and RSC4. The RSC complex consists at least of fifteen subunits, one of them being either RSC1 or RSC2. Neither RSC1 nor RSC2 is essential for viability, suggesting that they have some redundant function [ 1 ].

RSC is involved in transcription regulation and nucleosome positioning [ 2 ]. It is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA [ 3 ]. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. The remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organisation of the cellular cytoskeleton [ 4 , 5 , 6 ].In addition to being essential for mitotic growth, the RSC complex is also required for sporulation [ 7 ].

1. Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains. Mol. Cell 4, 715-23
2. RSC, an essential, abundant chromatin-remodeling complex. Cell 87, 1249-60
3. Histone octamer transfer by a chromatin-remodeling complex. Cell 96, 389-92
4. Functional differences between RSC1 and RSC2, components of a for growth essential chromatin-remodeling complex of Saccharomyces cerevisiae, during the sporulation process. FEMS Yeast Res. 2, 87-91
5. Chromatin remodeling by RSC involves ATP-dependent DNA translocation. Genes Dev. 16, 2120-34
6. Yeast RSC function is required for organization of the cellular cytoskeleton via an alternative PKC1 pathway. Genetics 161, 575-84
7. RSC1 and RSC2 are required for expression of mid-late sporulation-specific genes in Saccharomyces cerevisiae. Eukaryotic Cell 3, 910-8