InterPro domain: IPR027157

Nuclear cap-binding protein subunit 2 (NCBP2, also known as CBC2 and CBP20) forms the CBC complex with the nuclear cap-binding protein subunit 1 ( IPR027159 ). The CBC complex binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs [ 1 , 2 , 3 , 4 ]. In humans, the CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus and plays a central role in nonsense-mediated mRNA decay (NMD) [ 5 ]. During cell proliferation, the CBC complex is involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference [ 6 ].

1. Importin provides a link between nuclear protein import and U snRNA export. Cell 87, 21-32
2. A cap-binding protein complex mediating U snRNA export. Nature 376, 709-12
3. Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. Cell 106, 607-17
4. Ars2 regulates both miRNA- and siRNA- dependent silencing and suppresses RNA virus infection in Drosophila. Cell 138, 340-51
5. The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export. J. Biol. Chem. 282, 15645-51
6. Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Cell 138, 328-39