InterPro domain: IPR027108

Prp6/Prp1 is a component of the U4/U6-U5 snRNP complex, which is involved in pre-mRNA splicing [ 1 ]. This entry also includes Prp6/Prp1 homologue, stabilised 1 (STA1, AT4G03430), from Arabidopsis [ 2 ]. STA1 is involved in the biogenesis of microRNAs and RNA-directed DNA methylation [ 3 , 3 ].

1. Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc. Natl. Acad. Sci. U.S.A. 96, 7226-31
2. STA1, an Arabidopsis pre-mRNA processing factor 6 homolog, is a new player involved in miRNA biogenesis. Nucleic Acids Res. 41, 1984-97
3. The PRP6-like splicing factor STA1 is involved in RNA-directed DNA methylation by facilitating the production of Pol V-dependent scaffold RNAs. Nucleic Acids Res. 41, 8489-502