InterPro domain: IPR027084

The Mps1 family of protein kinases is a critical regulatorof genetic stability [ 1 , 2 ]. In yeast, Mps1 is required for the spindle checkpoint and SPBduplication [ 3 ]. Human Mps1, also known as TTK, is required for proper chromosome alignment on the metaphase plate and for the fidelity of chromosome segregation, and might also have a role at centrosomes [ 4 ]. It is associated with cell proliferation and involved in mitotic cell cycle checkpoint control [ 5 , 6 ]. In late mitosis, Mps1 is ubiquitinated by the APC/C and subsequently degraded [ 7 ]. The catalytic domain of Mps1 is in the C-terminal region, and the N-terminal region includes TPR repeats that promote homodimer formation [ 8 ].

1. A field guide to the Mps1 family of protein kinases. Cell Cycle 3, 439-42
2. Centrosomes and checkpoints: the MPS1 family of kinases. Oncogene 21, 6161-9
3. The yeast protein kinase Mps1p is required for assembly of the integral spindle pole body component Spc42p. J. Cell Biol. 156, 453-65
4. On the molecular mechanisms of mitotic kinase activation. Open Biol 2, 120136
5. Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. Development 129, 5141-9
6. Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. Genes Dev. 18, 1527-32
7. Degradation of the human mitotic checkpoint kinase Mps1 is cell cycle-regulated by APC-cCdc20 and APC-cCdh1 ubiquitin ligases. J. Biol. Chem. 285, 32988-98
8. Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases. J. Biol. Chem. 287, 5988-6001