InterPro domain: IPR027079
General Information
- Identifier IPR027079
- Description TFIIH subunit Tfb1/GTF2H1
- Number of genes 169
- Gene duplication stats Loading...
- Associated GO terms GO:0006351 GO:0000439 GO:0006289
Abstract
TFIIH is a eukaryotic complex composed of two subcomplexes, the CAK (Cdk activating kinase) and the core-TFIIH. This entry represents Tfb1/GTF2H1, a component of the core-TFIIH basal transcription factor, which consists of seven subunits known as XPB, XPD, GTF2H1 (p62), p52, p44, p34, and p8 in humans and Ssl2, Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and Tfb5 in yeast [ 1 ]. TFIIH is involved in nucleotide excision repair (NER) of DNA and RNA transcription by RNA polymerase II and I [ 2 , 3 , 4 ].
1. Functional insights into the core-TFIIH from a comparative survey. Genomics 19, 578-84
2. The yeast TFB1 and SSL1 genes, which encode subunits of transcription factor IIH, are required for nucleotide excision repair and RNA polymerase II transcription. Mol. Cell. Biol. 15, 2288-93
3. TFIIH plays an essential role in RNA polymerase I transcription. Cell
4. The transcriptional complexity of the TFIIH complex. Trends Genet. 109, 297-306