InterPro domain: IPR027031

This family includes both Glycyl-tRNA synthetases and mitochondrial DNA polymerase subunit gamma-2 (POLG2).

Glycyl-tRNA synthetase catalyses the attachment of glycine to tRNA(Gly). The DNA polymerase gamma-2 subunit acts as a processivity factor to stimulate the catalytic subunit of DNA polymerase gamma. Pol gamma-2 shares conserved sequence blocks with prokaryotic class II aminoacyl-tRNA synthetases, and these are necessary for activity and inter-action with the catalytic subunit [ 1 ].

1. Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase. Nucleic Acids Res. 28, 1237-44