InterPro domain: IPR026971

This entry includes condensin subunit 1 (CND1) and condensin-2 complex subunit D3 (NCAPD3).

CND1 is a regulatory subunit of the condensin complex (contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG), a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes [ 1 ]. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases [ 2 , 3 , 4 ].

NCAPD3 is a regulatory subunit of the condensin-2 complex (contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2) , a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis [ 5 ].

1. Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7. Mol. Cell. Biol. 22, 5769-81
2. Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior. Mol. Biol. Cell 13, 632-45
3. Phosphorylation and activation of 13S condensin by Cdc2 in vitro. Science 282, 487-90
4. Chromosome condensation by a human condensin complex in Xenopus egg extracts. J. Biol. Chem. 276, 5417-20
5. Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. Cell 115, 109-21