InterPro domain: IPR026941
General Information
- Identifier IPR026941
- Description F-box only protein 31
- Number of genes 3
- Gene duplication stats Loading...
- Associated GO terms GO:0031571 GO:0031146 GO:0030332 GO:0019005 GO:0006974
Abstract
F-box only protein 31 is a component of the SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognises phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest [ 1 , 2 ].
1. FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex. Cancer Res. 65, 11304-13
2. F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. Nature 459, 722-5
Species distribution
Gene table
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