InterPro domain: IPR026893

This is a family of putative tyrosine/serine-protein phosphatases. A member of this family, IphP, is a cyanobacterial dual-specificity protein phosphatase with MAP kinase phosphatase activity [ 1 , 2 ]. This entry also includes PtpB from Mycobacterium tuberculosis. PtpB is a phosphatase that possesses triple substrate specificity toward phosphotyrosine, phosphoserine/threonine and phosphoinositides [ 3 , 4 , 5 ].

1. A protein-tyrosine/serine phosphatase encoded by the genome of the cyanobacterium Nostoc commune UTEX 584. J. Biol. Chem. 268, 7632-5
2. Substrate specificity of IphP, a cyanobacterial dual-specificity protein phosphatase with MAP kinase phosphatase activity. Biochemistry 35, 7566-72
3. Cloning and characterization of secretory tyrosine phosphatases of Mycobacterium tuberculosis. J. Bacteriol. 182, 5425-32
4. Mycobacterium tuberculosis protein tyrosine phosphatase PtpB structure reveals a diverged fold and a buried active site. Structure 13, 1625-34
5. MptpB, a virulence factor from Mycobacterium tuberculosis, exhibits triple-specificity phosphatase activity. Biochem. J. 406, 13-8