InterPro domain: IPR026886

Pexophagy is an autophagic process consisting of the rapid and selective degradation of peroxisomes. Autophagy-related protein 2 (ATG2) is required for glucose-induced micropexophagy and ethanol-induced macropexophagy in yeast [ 1 , 2 ]. ATG2 is also involved in pexophagy in plants [ 3 ].

This family also includes uncharacterized proteins from invertebrates.

1. GSA11 encodes a unique 208-kDa protein required for pexophagy and autophagy in Pichia pastoris. J. Biol. Chem. 276, 42422-35
2. Paz2 and 13 other PAZ gene products regulate vacuolar engulfment of peroxisomes during micropexophagy. Genes Cells 7, 75-90
3. Highly oxidized peroxisomes are selectively degraded via autophagy in Arabidopsis. Plant Cell 25, 4967-83