InterPro domain: IPR026885

This entry represents the autophagy-related protein 2 CAD motif. The Atg2 protein, an integral membrane protein, is required for a range of functions including the regulation of autophagy in conjunction with the Atg1-Atg13 complex [ 1 , 2 , 3 ]. The precise function of this region, with its characteristic highly conserved CAD sequence motif, is not known.

1. Apg2 is a novel protein required for the cytoplasm to vacuole targeting, autophagy, and pexophagy pathways. J. Biol. Chem. 276, 30442-51
2. The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. Dev. Cell 6, 79-90
3. Autophagy: molecular machinery for self-eating. Cell Death Differ. 12 Suppl 2, 1542-52