InterPro domain: IPR026850

This entry represents the C-terminal domain of the FANCL, which is the E3 ubiquitin ligase subunit of the FA (Fanconi anaemia) complex [ 1 , 2 , 3 , 4 ]. This entry also consists of structure-specific endonuclease subunit slx1.

1. The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly. J. Biol. Chem. 281, 10896-905
2. Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway. J. Biol. Chem. 286, 32628-37
3. Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection. Structure 22, 337-44
4. The structure of the catalytic subunit FANCL of the Fanconi anemia core complex. Nat. Struct. Mol. Biol. 17, 294-8