InterPro domain: IPR026829

Monensin-resistant homologue 2 (Mon2) is a peripheral membrane protein involved in multiple aspects of endomembrane trafficking [ 1 , 2 ]. In Drosophila it has been described to couple endocytosis with actin remodeling [ 3 ]. In budding yeast, Mon2 plays a role in endocytosis and maintenance of vacuolar structure [ 4 , 5 ]. Mon2 is distantly related to the guanine nucleotide exchange factors (GEFs) that activate Arf1 on Golgi membranes. However, Mon2 lacks the Sec7 domain that catalyses nucleotide exchange on Arf1 [ 6 ]. In Drosophila it has been described to couple endocytosis with actin remodeling [ 6 ].

1. Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions. EMBO J. 27, 1647-57
2. Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-to-vacuole transport pathway and is required for Golgi homeostasis. J. Cell. Sci. 118, 4751-64
3. Drosophila Mon2 couples Oskar-induced endocytosis with actin remodeling for cortical anchorage of the germ plasm. Development 138, 2523-32
4. Yeast Ysl2p, homologous to Sec7 domain guanine nucleotide exchange factors, functions in endocytosis and maintenance of vacuole integrity and interacts with the Arf-Like small GTPase Arl1p. Mol. Cell. Biol. 22, 4914-28
5. Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus. J. Biol. Chem. 281, 2273-80