InterPro domain: IPR026825
General Information
- Identifier IPR026825
- Description Vacuole morphology and inheritance protein 14
- Number of genes 248
- Gene duplication stats Loading...
- Associated GO terms GO:0070772 GO:0006661
Abstract
Vac14 is a component of the PI(3,5)P2 regulatory complex, which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) [ 1 ]. This complex is composed of Atg18, Fig4, Fab1, Vac14 and Vac7 in yeast. In mammals it consists of PIKfyve, FIG4 and VAC14. Fab1/PIKfyve (Fab1 in yeast and PIKfyve in mammals) is a kinase that converts PI(3)P into PI(3,5)P2 by phosphorylation at the 5-position; conversely Fig4 dephosphorylates PI(3,5)P2 back to PI(3)P. Vac14 is a scaffolding adaptor protein whose multimerisation is a prerequisite step for PI(3,5)P2 complex assembly and function [ 2 ].
1. VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J. 27, 3221-34
2. Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function. J. Biol. Chem. 288, 9363-72