InterPro domain: IPR026797

This entry represents subunit 6 of the HAUS augmin-like complex, involved in mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis [ 1 , 2 ]. Subunit 6 interacts with the NEDD1-gamma-tubulin complex and recruits this complex to the spindle, which in turn promotes microtubule polymerisation [ 3 ].

Although plant cells assemble the mitotic spindle in the absence of the centrosome structure, they also possess an augmin complex with similar functions in microtubule nucleation and organisation. The Arabidopsis augmin complex contains both conserved and unique subunits compared with its animal counterparts [ 4 ]. This entry includes plant AUGMIN subunit 6 (AUG6).

1. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Proc. Natl. Acad. Sci. U.S.A. 106, 6998-7003
2. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr. Biol. 19, 816-26
3. FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle. J. Cell Biol. 183, 835-48
4. Characterization of the Arabidopsis augmin complex uncovers its critical function in the assembly of the acentrosomal spindle and phragmoplast microtubule arrays. Plant Cell 24, 1494-509