InterPro domain: IPR026740

General Information

  • Identifier IPR026740
  • Description AP-3 complex subunit beta
  • Number of genes 149
  • Gene duplication stats Loading...
  • Associated GO terms GO:0016192   GO:0030123  

Abstract

The AP-3 complex functions in cargo-selective protein transport from the Golgi to the vacuole/lysosome [ 1 ]. It is an adapter-related complex which is thought not to be clathrin-associated. The AP-3 complex facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. It is required for the transport via the ALP pathway [ 2 ]. In neurons, AP-3 generates synaptic vesicles or vesicles carrying synaptic vesicle membrane proteins [ 3 ].

This entry represents the beta subunit of the AP-3 complex.


1. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell 91, 109-18
2. The AP-3 complex: a coat of many colours. Trends Cell Biol. 8, 282-8
3. Neuronal and non-neuronal functions of the AP-3 sorting machinery. J. Cell. Sci. 120, 531-41

Species distribution

Gene table