InterPro domain: IPR026721

General Information

  • Identifier IPR026721
  • Description Transmembrane protein 18
  • Number of genes 142
  • Gene duplication stats Loading...

Abstract

This entry represent the transmembrane protein 18 (TMEM18). In humans, TMEM18 is a transcription repressor and a sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats [ 1 ]. It enhances the tropism of neural stem cells for glioma cells [ 2 ].


1. Obesity risk gene TMEM18 encodes a sequence-specific DNA-binding protein. PLoS ONE 6, e25317
2. Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells. Cancer Res. 68, 4614-22

Species distribution

Gene table